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For more than a decade the World Health Organization (WHO) has published a report highlighting the relevance of considering low adherence to treatment in health policy decisions and its marked economic and health consequences [9]

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Structural and functional changes of the BBB in PD Evidence for increased BBB permeability in human postmortem tissues Early attempts to study BBB permeability in PD did not detect overt disruptions, although the presence of mononuclear cells infiltrating the substantia nigra and the striatum suggested neuroinflammation, a major BBB disruptor [115,116,117]

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[10] So, as long as we're asking, "Is berberine nature's Ozempic?", we should also ask if berberine is nature's metformin