Specific cardiac considerations include: Heart rhythm concerns: The heart rate-increasing effect may require additional monitoring in patients with atrial fibrillation, supraventricular tachycardia, or ventricular arrhythmias Heart failure: Patients with New York Heart Association (NYHA) Class III-IV heart failure were excluded from major clinical trials, and there is limited safety data in this population [18] [21] Recent cardiac events: Patients with recent myocardial infarction, stroke, or unstable angina may require individualized assessment during the recovery period Hemodynamic considerations: Rapid weight loss may affect fluid balance in patients with significant cardiac disease Adverse effects relevant to cardiac patients include gastrointestinal symptoms (nausea, vomiting, diarrhea) that may lead to dehydration and electrolyte disturbances

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Efficacy of high-intensity laser therapy in comparison with conventional physiotherapy and exercise therapy on pain and function of patients with knee osteoarthritis: a randomized controlled trial with 12-week follow up. Lasers in medical science 34.3 (2019): 505-516
But the moment you reintroduce liquid, you're bringing that delicate structure back to life, and it's incredibly vulnerable
Use of chlorotoxin for targeting of primary brain tumors
doi: 10.1016/j.cmet.2013.04.008