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Olcay et al

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Nevertheless, the field is still grappling with questions about subtle or rare effects- for instance, whether nanoparticles might trigger unexpected immune responses or cross the bloodbrain barrier and elicit neuroeffects (211213)

Meta-evaluation of meta-analysis: ten appraisal questions for biologists

That separation is clinically documented and is the reason researchers continue to study this molecule despite the commercial development programme ending in 2007

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