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GLP-1 therapies have rapidly become top drivers of drug spend

However, when incorporating classes derived from a LCA model into subsequent statistical models, it is essential to account for the inherently probabilistic nature of class membership

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While most reviews reported the total number of excluded primary studies and general exclusion criteria, few provided detailed justifications for individual exclusions

doi: 10.1007/s12035-016-0117-0 90 KosarajuJMurthyVKhatwalRBDubalaAChinniSMuthureddy NatarajSKet al

Do not rush dose escalation The standard escalation schedule exists for a reason