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For context, total plasma volume in a 70-kg adult is about 3 L, so 12.5 L indicates moderate extravascular distribution

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If the next dose is less than 3 days away, skip the missed dose and resume on schedule

The idea is to maintain the progress youve made while keeping the medication comfortable to take over time

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In plain terms, it works more like a timed release that depends on your metabolism than a switch that flips on quickly