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PharmGKB (Pharmacogenetics and Pharmacogenomics Knowledge Base) (Whirl-Carrillo et al., 2021): A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers

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Sharma et al., 2024a)

Providing detailed evidence of these practices can prompt investigations and potential enforcement actions

The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A

Additionally, the 2008 PE/HR estimates were based on the observations (about half of responses) that had no missing expense data, whereas the 2024 PE/HR estimates and the shares are based on observations that had at least some non-missing data where the missing data was imputed as described in the Survey Methods Report (Step 6)