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Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A

Iron ions in the form of Fe 2+ or Fe 3+ reside in cells i n vivo, and iron homeostasis maintains the relatively stable content of these ions through transferrin receptor 1 (TFR1)-regulated iron transport, ferroportin 1 (FPN1)-mediated iron output storage, and ferritin-regulated iron storage (Fig

J., et al., 2006, American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 141B: 947-956)

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Notably, these alterations occur prior to the onset of inflammation and induce the upregulation of epithelial-derived cytokines such as thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33), which subsequently activate the Th2 immune axis in a sustained manner (Jo et al., 2018