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Group IV comprises 15 H.pylori -positive duodenal ulcer patients treated with nizatidine (300 mg once daily at bedtime for 6 weeks) in combination with thioctic acid (300 mg once daily for 6 weeks)

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It is well tolerated, easy for patients to self-administer, and it keeps mitochondrial support steady through the period when the body is doing the most cellular work

In addition, BMI was significantly positive correlated with FAP and autophagy markers

When participants stopped taking SFN, some behavioral improvements diminished, suggesting that the benefits are closely tied to ongoing treatment

However, treatment with S1P significantly reduced vacuole numbers in irradiated cells, suggesting a role of S1P in inhibiting autophagy, which typically promotes ferroptosis via GPX4 degradation [101, 102] and iron release from ferritin [19]