Ann Neurol (2021) 90(2):22738
GLP-1 medications work partly by suppressing appetite and slowing gastric emptying. That's the mechanism behind the weight loss. But less food in means fewer vitamins and minerals in and the research now shows this isn't a theoretical concern. Butsch et al. (2025), the largest of the six studies in the Urbina review, tracked 461,382 GLP-1 users and found 22.4% had a new nutritional deficiency diagnosis within 12 months. Vitamin D was most common (13.6%), followed by nutritional anemia (4%), iron deficiency (3.2%), and B vitamin deficiency (2.6%). In a smaller dietary study (Johnson et al. 2025, Frontiers in Nutrition), 64% of GLP-1 users didn't meet iron intake recommendations, and 72% fell short on calcium.* This GLP-1 supplement covers the five most at-risk nutrients with bioavailable forms: methylcobalamin B12, chelated iron, chelated zinc, 5-MTHF folate, and vitamin D3
The tasty way to get the benefits: Aim for at least two servings of beef, poultry, fish and eggs paired with two servings of cheese daily
The irony is that the weight loss theyre chasing for shape or aesthetics can be undermined by losing the very muscle that defines that shape without structured support
Costs can be in the single millions for small molecules compared to mid- to high tens of millions for peptides
Ive been on it for 3 months and lost35 pounds
