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At this point, the injured brain tissue rapidly produces pro-inflammatory cytokines, causing leukocyte infiltration and eventually inducing ferroptosis and exaggerating brain edema, neuron death and progress of IS (Jin et al., 2013) (Figure 2)

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The study focused on a section known as HERV-K, which is an endogenous retrovirus found in the non-coding part of the genome

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10.1038/jcbfm.2009.248 96

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Adding or optimizing the microneedling component significantly increases the amount of PTD-DBM reaching target cells

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