In terms of systemic infection and prognosis, although the polymorphism of Dectin-1/CARD9 is not consistently associated with the susceptibility to Candida bloodstream infection, the responses of the heterozygous Y238X carriers to cytokines in vitro are weakened, which may affect the inflammatory regulation and prognosis of severe infections (Rosentul et al., 2011)
Emergence of non-albicans Candida species and antifungal resistance in intensive care unit patients
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Mice lacking ARs unveiled neutropenia owing to reduced proliferation of the precursor cells, ultimately compromising the host defense against microbial infections (55)
The timeline varies depending on injury severity
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