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N -terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases

Clin Kidney J 15:16751684

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Apollo-NADP(+): a spectrally tunable family of genetically encoded sensors for NADP(+)

doi: 10.2463/mrms.mp.2016-0149 121 TestaACTimmermanDVan HolsbekeCZannoniGFFransisSMoermanPet al

Major Organizations Several key organizations play pivotal roles in shaping the landscape of functional medicine: The Institute for Functional Medicine (IFM): As the leading voice for functional medicine globally for over 30 years, IFM is arguably the most prominent organization in the field