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Its key disadvantage today is that it is not yet available
Additionally, bacteria can develop resistance mechanisms such as modifying membrane charge, producing proteases, altering metabolism, or forming biofilms, which can reduce LL-37s effectiveness
Because it is naturally found in the stomach, it possesses an inherent resistance to degradation, making it more robust in various experimental environments
In PD, mitochondrial complex I defects increase electron leakage from the ETC) elevating superoxide production [98]
doi: 10.1002/mds.25585
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