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Fortunately, advanced medications like Tirzepatide and the emerging Retatrutide offer promising pathways to break through these metabolic barriers and resume weight loss progress

It functions as a dual GLP-1 and GIP agonist and reduces patient obesity by nearly 22.5% of their BW by 72 weeks in Phase III SURMOUNT-1 human trials

However, if significant mood symptoms emerge, consider reducing dose or discontinuing

How the dual GLP-1 and GIP mechanism works To understand why a dual agonist outperforms a single agonist, you need to understand what each receptor does independently and what happens when both are activated together