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Science 207 , 653655 (1980)

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[14] Although HVR1 is quite variable in amino acid sequence, this region has similar chemical, physical, and conformational characteristics across many E2 glycoproteins

Melatonin may be pertinent in PCOS as it is believed to directly diminish testosterone production through its anti-gonadal effects, alongside its advantageous roles in alleviating insulin resistance, hyperglycemia, and dyslipidemia [181]