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Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers

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The mortality rate increased by 32% from 1990 to 2019 (52)

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Symptoms as Toxicity Develops As the combined depressant load increases, the following symptoms become more likely and more severe than with GHB alone: Deepening sedation that becomes impossible to fight Vomiting while consciousness is reduced, creating a serious aspiration risk Significant drops in blood pressure Slowed or shallow breathing Falling oxygen levels Loss of the gag reflex that normally protects the airway Abrupt loss of consciousness or coma The vomiting and sedation combination is especially dangerous