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There are various treatment options available for melasma

For example, while the maximum daily dose of acetaminophen was previously set at 4 g/day, the FDA Advisory Committee suggests decreasing it in an effort to reduce overdoses

It varies by individual and treatment

In such a situation, the doctor may recommend an oophorectomy or a surgery to remove their ovaries which could reduce the amount of estrogen in their body.

Wan T, Wang S, Ye M, Ling W, Yang L (2017) Cyanidin-3-O--glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPK/autophagy signaling pathway

Remaining hydrated is also important, so make sure you drink water