Discontinuing the meds often leads to regaining much of the weight youve lost, once you lose the benefits that the GLP-1 drugs provide
The decision to initiate pharmacotherapy requires shared decision-making, discussing realistic expectations, potential adverse effects, cost considerations, and the likely need for indefinite treatment duration
P., et al
GLP-1 Receptor Agonists Overview
GLP-1 is primarily produced by specialised cells called L-cells , which are enteroendocrine cells located predominantly in the distal small intestine (ileum) and colon
Key timing considerations: Broader Tmax window (8 to 72 hours) means less precision in predicting peak effects Dual GIP/GLP-1 mechanism may produce a different side effect timing pattern than pure GLP-1 agonists Body aches and muscle pain may peak later than GI symptoms, around 24 to 48 hours post-injection Consider how tirzepatide affects metabolism throughout the weekly cycle The appetite suppression timeline may differ from semaglutide due to the dual mechanism Dose escalation timing: Tirzepatide starts at 2.5mg weekly, escalating to 5mg after 4 weeks
