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Its worth stating that most clinical trials, even the largest ones, deliver average effects of treatments, and very few trials can reliably estimate treatment-effect differences in subgroups, and even fewer can estimate individualized responses to treatments

Unlike allopurinol, however, early in therapy probenecid can increase urinary uric acid, which could lead to the development of a kidney stone

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14.9% Average body weight lost by non-diabetic obese adults at 68 weeks STEP 1 Trial, NEJM 2021 People are taking various medications and opting for different treatments to lose weight