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In a murine model of renal cell carcinoma, upregulation of G6PD and subsequent increase in NADPH was found to inhibit ferroptosis whereas G6PD knockdown in human hepatocellular carcinoma cells increased positive regulators of ferroptosis 83,84,85

Validation of L2-Cmu was confirmed by Biacore analysis and in murine fibroblasts (NIH-3T3) in vitro

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Laboratory studies have investigated MOTS-c for roles in cellular metabolism, AMPK signalling, and metabolic stress responses

Sullivan et al., 2000) of phosphorylative cascade, MAPKs (Filomeni et al., 2005c

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