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Many other drugs decrease GSH levels because they induce oxidative stress, for example doxorubicin (adriamycin), antimalarial drugs, chloroquine (CQ), etoposide, opiates, ethanol [84] and antidepressants [85]

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With this increased availability of therapeutic choices that may address various unmet priority needs, the question of rational combination(s) in T2DM holds deeper and broader implications today