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Furthermore, the expression of cathepsin B and cystatin C was significantly increased at both gene and protein levels in mice with an experimental model of AMD, which further strengthened the association of these two enzymes with the development of AMD [59]

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In this recently classified subcategory of liver disease, the co-existence of diet-induced obesity (a metabolic factor) and moderate to high amounts of alcohol consumption creates a double-hit injury

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10.1038/s41574-023-00821-8 3 BeccutiG.BiolettoF.Parasiliti-CaprinoM.BensoA.GhigoE.CicolinA.et al (2024)