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Results of two randomized placebo-controlled trials of liraglutide in patients with advanced systolic heart failure, with or without diabetes, failed to demonstrate benefit of liraglutide, and the trend in both trials was worse outcomes with liraglutide versus placebo

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Weight Loss and Insulin Resistance: The Connected Pathway Excess abdominal fat, particularly visceral fat around organs, actively produces inflammatory compounds that interfere with insulin receptor signaling