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Distinct proteomic and post-translational impacts of class-defining AML alterations To explore the imprint of recurrent genetic alterations on the AML proteome, we linked common genetic alterations to differences in the abundance of proteins and PTMs (Methods)

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We applied rigorous methodology, including PSM, and compared tirzepatide with other active anti-obesity medications to ensure balanced and robust comparisons

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Doses varied significantly depending on the animal and application, ranging from as low as 400 ng/animal for intracardiac injection in mice, to 15 mg/animal for retroinfusion in 25 kg German pigs, and up to 60 mg/kg for larger animals in toxicity assessments

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Joseph Chandy estimates that 1 in 10 people experience this phenomenon

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