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Nitric oxide appears to influence Akt signaling though a cGMP/PI3K-dependent pathway [26], which is the primary pathway for up-regulating translation initiation and protein synthesis in skeletal muscle

L-methymalonyl-CoA mutase converts L-methymalonyl-CoA to succinyl-CoA, which is essential for the metabolism of protein and fat

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In summary, we present a panoptic analysis of the role of mitochondrial metabolism in dictating sensitivity to 5FU, the most commonly used chemotherapy worldwide

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