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In contrast, a number of patients with lipodystrophy show hypertension in the leptin-deficient state [263, 264]

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It was first isolated in 1973 by Dr

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Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-2 28 (Figure 1)