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The timing of symptom onset varies by medication

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In response, semaglutide and tirzepatide were added to the FDA Drug Shortages Database, allowing compounding pharmacies to produce generic versions

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Such modifications then activate NF-B that is involved in the expression of proinflammatory mediators such as TNF and IL-6, 343,344 and that induces key steroidogenic molecules, like CYP11A1, CYP17A1 and StAR, leading to further aggravation of hyperandrogenemia