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Retrieved on February 17, 2025 from O'Neil, P

At this stage, weight loss often stabilizes into a steady pattern of one to two pounds per week, though some people experience natural plateaus lasting a week or two before dropping again

Each trip introduces risk

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The figures below come from each drug's own trials, so treat them as a general guide rather than a direct comparison

And retatrutide (Eli Lilly, phase III ongoing) aims higher still: triple GLP-1 + GIP + glucagon activity, redefining the upper ceiling of metabolic efficacy