GLP-1 is primarily secreted by the L-cells in the small bowel (35)
"MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis." Nature Communications , 12, 470
Phase 2 data published in The New England Journal of Medicine in 2023 suggest meaningful weight reductions can begin within the first few months of treatment, with results continuing to build over 48 weeks
Always consult with your doctor before taking a new supplement, especially if youre on other medications, like semaglutide, and have side effects
As of March 2026, just 13 state Medicaid programs cover GLP-1 medications, including Ozempic, for obesity treatment: Delaware Kansas Massachusetts Michigan Minnesota Mississippi Missouri North Carolina Rhode Island Tennessee Utah Virginia Wisconsin Medicaid programs in California, New Hampshire, Pennsylvania, and South Carolina all recently ended obesity drug coverage, citing the steep cost of these medications
This gastrointestinal symptom stems from how GLP-1 receptor agonists slow stomach emptying and signal fullness to your brain
