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J Med Chem 2017

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Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts

Multiple clinical studies document GHRP-2 producing statistically significant cortisol and ACTH elevations alongside GH release

TB-500 is thought to work systemically, meaning it circulates throughout the body rather than acting only at the injection site