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these were dichotomised as 01 (less than moderate-severe) vs 24 (moderate-severe)

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Compared to GLP-1, semaglutide carries a substitution of the alanine at position 8 with -aminoisobutyric acid (Aib) and acylation of the lysine at position 26 with a fatty di-acid side chain for extended half-life, which is linked via a linker sequence