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In both microglia and astrocytes, this mechanism amplifies inflammation when activated by protein aggregates such as A and -synuclein that build up in neurodegenerative diseases [451, 452]
impact of ascorbic acid and glutathione
2022;44(12):e2938
As a result, the reduction of negative consequences caused by ROS becomes insufficient (Jeek et al
High levels of iron and/or ferritin have been detected in the airways of individuals with COPD and cystic fibrosis, and in heavy smokers, suggesting dysregulation of iron homeostasis in these conditions (Stites et al., 1999