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Specific intervention scenarios of GLP-1 on cellular energy economics Treatment of diabetes: correcting the "imbalance of energy distribution" The core pathology of type 2 diabetes is insulin resistance and beta cell function failure, which leads to the imbalance of energy distribution: the intake of glucose by muscle and adipose tissue is reduced, the liver gluconeogenesis is increased, and the levels of glucose and FFA in the blood are increased, forming a vicious cycle of "hyperglycemia hyperlipidemia"

SELECT (Lincoff et al., NEJM 2023)

A.HolmJ

doi: 10.1177/1479164113481817 15 McCleanPParthsarathyVFaivreHlscherC

Diabetes 54, 2988-2994

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