May 2006;101(5):1080-3
In addition, circulating GLP-1 enters circumventricular areas of the CNSsuch as the subfornical organ, the organum vasculosum of the lamina terminalis, the median eminence near the arcuate nucleus, and the area postremathanks to the partial permeability of the bloodbrain barrier.2,3,6 In addition, NTS neurons, which receive peripheral afferent input, synthesise preproglucagon and serve as a source of GLP-1 within the CNS
In the presence of GSH, as shown in Fig
After this period, its effectiveness may begin to decline
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