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Leptin produced by fat cells, leptin signals satiety and helps regulate long-term energy balance

This insight comes from in vitro studies, which means studies done on cells isolated outside of the body (imagine scientists looking under a microscope at a petri dish)

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Numerous studies confirm that insufficient sleep can negatively affect health, including cognitive function decline [1], emotional disorders [2], increased risk of cardiovascular and cerebrovascular diseases [3, 4], and impaired immune function [5]

This is the starting line

[Blog] Cost-Effectiveness Models Assume Patients You Don't Have is the clearest counter-signal