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In the hippocampus and cortex, CB 1 Rs have an especially high localization on inhibitory neurons, although their distribution and localization patterns differ throughout the human and rodent CNS (Glass et al., 1997

Additionally, other factors such as having had gastric bypass surgery or taking antacids long-term can lead to deficiency

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The current evidence suggests that the peptide exerts its activity through interactions with amylin receptors and related receptor complexes

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