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Mutational effect on allostery Protein structure was prepared for point mutation using Chimera rotamers tool (In structure editing section) 29,49

Liver cells engulf damaged partsmisfolded proteins, worn mitochondriafor recycling

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Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism

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Therefore, to address this critical gap, we designed a comprehensive preclinical study to dissect the specific effects of Retatrutide on adipose tissue in a model of high-fat diet (HFD)-induced obesity