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J., Rosenstock, J., Anzalone, D., Tou, C

A marked increase in pain accompanied by local swelling, further restriction of joint motion, fever, and malaise are suggestive of septic arthritis

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Other important aspects include for example genome instability, telomere attrition, epigenetic alterations, cellular senescence, chronic inflammation and dysbiosis that can be collectively referred to as hallmarks of aging [5]