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The reconciling pharmacology has not been settled in the peer-reviewed literature

Women in this category often do best with Protocol 1 (the gentle start) with an additional modification: extending each dose level by one to two weeks during periods of noticeable hormonal fluctuation

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Biomarker and Genetic Factors That May Shape GLP-1 Response in Migraine Your genetic predispositions in GLP-1 and metabolic pathways may influence how your body responds to these medications

(December 1995)

While some studies report GLP-1 increases, there is no evidence these translate to meaningful weight loss or metabolic improvements