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Studies showed that TGF- induces the expression of the de novo serine [phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1) and phosphoserine phosphatase (PSPH)] and glycine [serine hydroxymethyltransferase 2 (SHMT2)] synthesis pathways in human fibroblasts (225)

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But the confusion multiplies when your pharmacy changes concentrations between refills, or when you switch from one compounding pharmacy to another

Schooneman, M.G., Vaz, F.M., Houten, S.M., & Soeters, M.R