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In addition, carnosine can activate the NRF2 pathway, leading to the upregulation of some ROS-detoxifying enzymes, such as the glutathione S-transferase (GST) protein family 24

Stimulators of endogenous NO production decrease renal cortical oxygen consumption more prominently in WKY than they do in SHR 54

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Therefore, a cautious interpretation is required with respect to whether U0126 executes its function through ERK inactivation or anti-oxidative activity