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both antibiotic use and germ-free conditions suppress the expression of CYP7A1 and CYP27A1, key enzymes involved in BA production based on animal mechanistic studies (Chiang and Ferrell, 2019)

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Sci Rep 7:45963 Von Fricken M, Weppelmann T, Eaton W, Masse R, Madsen VE, De Rochars B et al (2014) Performance of the carestart glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in Gressier, Haiti

Meanwhile, this strain can induce IL-10 secretion by secreting polysaccharide A (PSA), synergistically promote Treg proliferation, reduce the levels of pro-inflammatory cytokines such as TNF- and IL-6, and thus inhibit the systemic inflammatory response in RA

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