Health Canada has approved six medications specifically for chronic weight management: orlistat (Xenical), liraglutide (Saxenda), naltrexone-bupropion (Contrave), semaglutide (Wegovy), tirzepatide (Zepbound), and setmelanotide (Imcivree, for rare genetic forms of obesity only)
By reducing appetite and slowing digestion, it helps some people lose a significant amount of weight
More serious risks discussed in class labeling include pancreatitis and gallbladder problems, and the approved products carry contraindications related to a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
Zepbound severe diarrhea including watery diarrhea, liquid diarrhea, or explosive episodes increases the risk of dehydration and, rarely, acute kidney injury, a complication explicitly noted in the FDA Zepbound prescribing information
Depending on the goals and specific needs for iPSC-HLCs as an in vitro model system, a dedifferentiated state might be preferable, for example, during investigation of liver regeneration mechanisms
In fact, emerging research continues to highlight the importance of gut health in nearly every aspect of wellness
