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Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6
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963 The main challenge of oligonucleotide therapy is to achieve effective and targeted delivery to tissues and cells
Under the estates management, debt was reduced, assets were reorganised, and commercial projects expanded, including MJ: The Musical and licensing agreements
doi: 10.4103/0019-5545.58891
