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A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization

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[1] When both agents place simultaneous load on glutathione-S-transferase pathways, a cautious clinician would want baseline liver function tests (LFTs) and periodic monitoring

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With ongoing research and advancements in understanding and treating CVS, there is hope for a better future for those living with this disorder

Citation: Minakova E, Lang J, Medel-Matus J-S, Gould GG, Reynolds A, Shin D, et al