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Our choice of an active-comparator design was intended to reduce confounding by indication, severity of diabetes mellitus and unmeasured clinical characteristics, as basal insulin is used in similar clinical settings and stages of type 2 diabetes as GLP-1RAs [16]

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The next, phase 1b clinical trial in adults with T2DM compared once weekly retatrutide (0.5, 1.5, 3, 3 mg starting dose increased to 6, 3 mg starting dose increased to 12 mg) versus placebo versus dulaglutide 1.5 mg over 12 weeks [63]

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Spectral-domain OCT