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Inhibition of the first rate-limiting enzyme of one-carbon metabolism (PHGDH) has been shown to promote cell growth arrest, a phenomenon that occurs as a result of an accumulation of intracellular reactive oxygen species (ROS) following the inhibition of glutamine metabolism

J Thorac Oncol

Read professional profile Dr Giedre Narkiene Medical doctor and board certified dermatologist with expertise in medical and cosmetic dermatology, skin health and patient safety

Levels of this antioxidant also dip with age

P.WilliamsK

Glutathione is rapidly oxidized in the gastrointestinal tract, making standard forms difficult to absorb and use effectively