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Long-acting GLP-1 receptor agonists improve glycemic control in type 2 diabetes patients while posing a low risk of hypoglycaemia due to their glucose-dependent mode of action

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Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes

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For RNAi-transfected cells and shRNA-transduced islets, sample insulin concentration was determined using the Insulin Ultra-Sensitive HTRF Assay kit (Cisbio) according to the manufacturers instructions