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Crystals can be taken up by mesenchymal dendritic cells via phagocytosis, a process that triggers the assembly and activation of NLRP3 inflammatory vesicles, leading to the release of IL-1, which in turn triggers the release of NF-kB-dependent cytokines and chemokines, amplifying the inflammatory response [323]

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Ludes PO, De Roquetaillade C, Chousterman BG, Pottecher J, Mebazaa A