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These enzymatic reactions profoundly influence energy homeostasis, repair capacity, cellular stress resistance, and gene expression Biological Activity NAD + is indispensable for over 400 cellular reactions, supports mitochondrial function, and modulates antioxidant defenses

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Mutations of collagen type II (specifically COL2A1) led to highly disorganised ECM deposition in transgenic mice, along with the total absence of endochondral bone or the epiphyseal growth plate [88]

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Were endpoints predefined, and were statistical methods clearly described